Hepatocellular carcinoma risk decreases as time accrues following hepatitis C virus eradication.

ABSTRACT:

Background

It is unclear whether the risk of hepatocellular carcinoma (HCC) decreases over time following hepatitis C virus (HCV) eradication.

Aim

To determine if patients who have accrued longer time since sustained virologic response (SVR) have a lower risk of HCC than those with less time since SVR METHODS: We conducted a retrospective cohort study of all HCV-infected Veterans Affairs patients who achieved SVR before 1 January 2018 and remained alive without a diagnosis of HCC as of 1 January 2019 (n = 75,965). We ascertained their baseline characteristics as of 1 January 2019 (time zero), including time accrued since SVR and followed them for the subsequent 12 months for incident HCC. We used multivariable Cox proportional hazards regression to determine the association

SUBMITTER: Vutien P 

PROVIDER: S-EPMC10842311 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature