Obesity alters the circadian profiles of energy metabolism and glucose regulation in humans.

ABSTRACT:

Objective

Given the complex interaction among the circadian system, energy metabolism, and obesity, the authors tested whether having obesity impacts the circadian variation in energy and glucose metabolism in humans.

Methods

Participants with BMI either in the healthy weight or obesity ranges were studied in a 5-day, in-laboratory protocol that equally distributed behaviors (i.e., sleep, eating, exercise) across 24 h. Energy metabolism was measured at rest and during a standardized exercise bout and blood was sampled before and after each identical study meal to assess glucose and insulin levels.

Results

In those with a healthy weight, the circadian nadir of energy expenditure, during both rest and exercise, occurred when participants would normally be asleep. Howeve

SUBMITTER: McHill AW 

PROVIDER: S-EPMC10842330 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature