MMP-2 Associates With Incident Heart Failure and Atrial Fibrillation: The ARIC Study.

ABSTRACT:

Background

MMP (matrix metalloproteinase)-2 participates in extracellular matrix regulation and may be involved in heart failure (HF), atrial fibrillation (AF), and coronary heart disease.

Methods

Among the 4693 ARIC study (Atherosclerosis Risk in Communities) participants (mean age, 75±5 years; 42% women) without prevalent HF, multivariable Cox proportional hazard models were used to estimate associations of plasma MMP-2 levels with incident HF, HF with preserved ejection fraction (≥50%), HF with reduced ejection fraction (<50%), AF, and coronary heart disease. Mediation of the association between MMP-2 and HF was assessed by censoring participants who developed AF or coronary heart disease before HF. Multivariable linear regression models were used to assess associations o

SUBMITTER: Buckley LF 

PROVIDER: S-EPMC10842537 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature