Hippocampal and medial prefrontal ensemble spiking represents episodes and rules in similar task spaces.

ABSTRACT: Episodic memory requires the hippocampus and prefrontal cortex to guide decisions by representing events in spatial, temporal, and personal contexts. Both brain regions have been described by cognitive theories that represent events in context as locations in maps or memory spaces. We query whether ensemble spiking in these regions described spatial structures as rats performed memory tasks. From each ensemble, we construct a state-space with each point defined by the coordinated spiking of single and pairs of units in 125-ms bins and investigate how state-space locations discriminate task features. Trajectories through state-spaces correspond with behavioral episodes framed by spatial, temporal, and internal contexts. Both hippocampal and prefrontal ensembles distinguish maze locations, t

SUBMITTER: Srinivasan A 

PROVIDER: S-EPMC10842596 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature