Predictive and diagnostic measures for kernicterus spectrum disorder: a prospective cohort study.

ABSTRACT:

Background

Kernicterus spectrum disorder (KSD) resulting from neonatal hyperbilirubinemia remains a common cause of cerebral palsy worldwide. This 12-month prospective cohort study followed neonates with hyperbilirubinemia to determine which clinical measures best predict KSD.

Methods

The study enrolled neonates ≥35 weeks gestation with total serum bilirubin (TSB) ≥ 20 mg/dl admitted to Aminu Kano Hospital, Nigeria. Clinical measures included brain MRI, TSB, modified bilirubin-induced neurologic dysfunction (BIND-M), Barry-Albright Dystonia scale (BAD), auditory brainstem response (ABR), and the modified KSD toolkit. MRI signal alteration of the globus pallidus was scored using the Hyperbilirubinemia Imaging Rating Tool (HIRT).

Results

Of 25 neonates enrolled, 13/25 c

SUBMITTER: Gelineau-Morel R 

PROVIDER: S-EPMC10842628 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature