Multimodal Imaging of Pancreatic Cancer Microenvironment in Response to an Antiglycolytic Drug.

ABSTRACT: Lipid metabolism and glycolysis play crucial roles in the progression and metastasis of cancer, and the use of 3-bromopyruvate (3-BP) as an antiglycolytic agent has shown promise in killing pancreatic cancer cells. However, developing an effective strategy to avoid chemoresistance requires the ability to probe the interaction of cancer drugs with complex tumor-associated microenvironments (TAMs). Unfortunately, no robust and multiplexed molecular imaging technology is currently available to analyze TAMs. In this study, the simultaneous profiling of three protein biomarkers using SERS nanotags and antibody-functionalized nanoparticles in a syngeneic mouse model of pancreatic cancer (PC) is demonstrated. This allows for comprehensive information about biomarkers and TAM alterations before an

SUBMITTER: Sheikh E 

PROVIDER: S-EPMC10842640 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature