Accumulation of advanced glycation end products in skin and increased vascular ageing in the general population: the Malmo Offspring Study.

ABSTRACT:

Objectives

Advanced glycation end product (AGE) is an established risk marker for diabetic vascular disease, and associated with the degree of diabetes complications, renal failure, and atherosclerosis in middle-aged and older individuals. The relationship between AGEs and aortic stiffness has not been thoroughly examined in the younger general population. We aimed to evaluate the association between AGEs and aortic stiffness in the general population of young and middle-aged adults.

Methods

We analysed cross-sectionally 2518 participants from a Swedish population-based cohort, the Malmö Offspring Study (mean age 41.8 ± 14.5 years, 52.2%). Advanced glycation end-products (AGEs) were measured by a well validated, noninvasive method using skin autofluorescence with AGE-Reader.

SUBMITTER: Jujic A 

PROVIDER: S-EPMC10842672 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature