Associations between Alzheimer's disease biomarkers and postoperative delirium or cognitive dysfunction: A meta-analysis and trial sequential analysis of prospective clinical trials.

ABSTRACT:

Background

The relationship between Alzheimer's disease biomarkers and postoperative complications, such as postoperative delirium (POD) and postoperative cognitive dysfunction (POCD), remains a subject of ongoing debate.

Objective

This meta-analysis aimed to determine whether there is an association between perioperative Alzheimer's disease biomarkers and postoperative complications.

Design

We conducted a meta-analysis of observational clinical studies that explored the correlation between Alzheimer's disease biomarkers and POD or POCD in patients who have undergone surgery, following PRISMA guidelines. The protocol was previously published (INPLASY: INPLASY202350001).

Data sources

A comprehensive search was conducted across PubMed, Embase, Web of Science, and

SUBMITTER: Geng J 

PROVIDER: S-EPMC10842675 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature