Relationship between brain structural network integrity and emotional symptoms in youth with perinatally-acquired HIV.

ABSTRACT: Perinatally acquired HIV infection (PHIV) currently affects approximately 1.7 million children worldwide. Youth with PHIV (YPHIV) are at increased risk for emotional and behavioral symptoms, yet few studies have examined relationships between these symptoms and brain structure. Previous neuroimaging studies in YPHIV report alterations within the salience network (SN), cognitive control network (CCN), and default mode network (DMN). These areas have been associated with social and emotional processing, emotion regulation, and executive function. We examined structural brain network integrity from MRI using morphometric similarity networks and graph theoretical measures of segregation (transitivity), resilience (assortativity), and integration (global efficiency). We examined brain network i

SUBMITTER: Caceres GA 

PROVIDER: S-EPMC10842701 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature