Sensory cortical ensembles exhibit differential coupling to ripples in distinct hippocampal subregions.

ABSTRACT: Cortical neurons activated during recent experiences often reactivate with dorsal hippocampal CA1 ripples during subsequent rest. Less is known about cortical interactions with intermediate hippocampal CA1, whose connectivity, functions, and ripple events differ from dorsal CA1. We identified three clusters of putative excitatory neurons in mouse visual cortex that are preferentially excited together with either dorsal or intermediate CA1 ripples or suppressed before both ripples. Neurons in each cluster were evenly distributed across primary and higher visual cortices and co-active even in the absence of ripples. These ensembles exhibited similar visual responses but different coupling to thalamus and pupil-indexed arousal. We observed a consistent activity sequence preceding and predicti

SUBMITTER: Jeong H 

PROVIDER: S-EPMC10842729 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature