Multi-scale model of axonal and dendritic polarization by transcranial direct current stimulation in realistic head geometry.

ABSTRACT:

Background

Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation modality that can alter cortical excitability. However, it remains unclear how the subcellular elements of different neuron types are polarized by specific electric field (E-field) distributions.

Objective

To quantify neuronal polarization generated by tDCS in a multi-scale computational model.

Methods

We embedded layer-specific, morphologically-realistic cortical neuron models in a finite element model of the E-field in a human head and simulated steady-state polarization generated by conventional primary-motor-cortex-supraorbital (M1-SO) and 4 × 1 high-definition (HD) tDCS. We quantified somatic, axonal, and dendritic polarization of excitatory pyramidal cells in layers 2/3

SUBMITTER: Aberra AS 

PROVIDER: S-EPMC10842743 | biostudies-literature | 2023 Nov-Dec

REPOSITORIES: biostudies-literature