Returning personal genetic information on susceptibility to arsenic toxicity to research participants in Bangladesh.

ABSTRACT:

Background

There is growing consensus that researchers should offer to return genetic results to participants, but returning results in lower-resource countries has received little attention. In this study, we return results on genetic susceptibility to arsenic toxicity to participants in a Bangladeshi cohort exposed to arsenic through naturally-contaminated drinking water. We examine the impact on behavioral changes related to exposure reduction.

Methods

We enrolled participants from the Health Effects of Arsenic Longitudinal Study who had (1) high arsenic (≥150 μg/g creatinine) in a recent urine sample and (2) existing data on genetic variants impacting arsenic metabolism efficiency (AS3MT and FTCD). We used genetic data to recruit three study groups, each with n = 103: (1

SUBMITTER: Tamayo LI 

PROVIDER: S-EPMC10842833 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature