Ambulatory 7-day mechanical circulatory support in sheep model of pulmonary hypertension and right heart failure.

ABSTRACT:

Background

Right heart failure is the major cause of death in pulmonary hypertension. Lung transplantation is the only long-term treatment option for patients who fail medical therapy. Due to the scarcity of donor lungs, there is a critical need to develop durable mechanical support for the failing right heart. A major design goal for durable support is to reduce the size and complexity of devices to facilitate ambulation. Toward this end, we sought to deploy wearable mechanical support technology in a sheep disease model of chronic right heart failure.

Methods

In 6 sheep with chronic right heart failure, a mechanical support system consisting of an extracorporeal blood pump coupled with a gas exchange unit was attached in a right atrium-to-left atrium configuration for up t

SUBMITTER: Ukita R 

PROVIDER: S-EPMC10842834 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature