A compartment model to predict in vitro finite dose absorption of chemicals by human skin.

ABSTRACT: Dermal uptake is an important and complex exposure route for a wide range of chemicals. Dermal exposure can occur due to occupational settings, pharmaceutical applications, environmental contamination, or consumer product use. The large range of both chemicals and scenarios of interest makes it difficult to perform generalizable experiments, creating a need for a generic model to simulate various scenarios. In this study, a model consisting of a series of four well-mixed compartments, representing the source solution (vehicle), stratum corneum, viable tissue, and receptor fluid, was developed for predicting dermal absorption. The model considers experimental conditions including small applied doses as well as evaporation of the vehicle and chemical. To evaluate the model assumptions, we co

SUBMITTER: Fisher HA 

PROVIDER: S-EPMC10842870 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature