Ontology highlight
ABSTRACT:
SUBMITTER: Hernandez-Reynoso AG
PROVIDER: S-EPMC10842897 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Hernandez-Reynoso Ana G AG Sturgill Brandon S BS Hoeferlin George F GF Druschel Lindsey N LN Krebs Olivia K OK Menendez Dhariyat M DM Thai Teresa T D TTD Smith Thomas J TJ Duncan Jonathan J Zhang Jichu J Mittal Gaurav G Radhakrishna Rahul R Desai Mrudang Spandan MS Cogan Stuart F SF Pancrazio Joseph J JJ Capadona Jeffrey R JR
Biomaterials 20231101
Intracortical microelectrode arrays (MEAs) are used to record neural activity. However, their implantation initiates a neuroinflammatory cascade, involving the accumulation of reactive oxygen species, leading to interface failure. Here, we coated commercially-available MEAs with Mn(III)tetrakis(4-benzoic acid)porphyrin (MnTBAP), to mitigate oxidative stress. First, we assessed the in vitro cytotoxicity of modified sample substrates. Then, we implanted 36 rats with uncoated, MnTBAP-coated ("Coate ...[more]