Neuronal NADPH oxidase is required for neurite regeneration of Aplysia bag cell neurons.

ABSTRACT: NADPH oxidase (Nox), a major source of reactive oxygen species (ROS), is involved in neurodegeneration after injury and disease. Nox is expressed in both neuronal and non-neuronal cells and contributes to an elevated ROS level after injury. Contrary to the well-known damaging effect of Nox-derived ROS in neurodegeneration, recently a physiological role of Nox in nervous system development including neurogenesis, neuronal polarity, and axonal growth has been revealed. Here, we tested a role for neuronal Nox in neurite regeneration following mechanical transection in cultured Aplysia bag cell neurons. Using a novel hydrogen peroxide (H₂ O₂ )-sensing dye, 5'-(p-borophenyl)-2'-pyridylthiazole pinacol ester (BPPT), we found that H₂ O₂ levels are eleva

SUBMITTER: Alam SMS 

PROVIDER: S-EPMC10842957 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature