Caveolae-associated cAMP/Ca²⁺-mediated mechano-chemical signal transduction in mouse atrial myocytes.

ABSTRACT: Caveolae are tiny invaginations in the sarcolemma that buffer extra membrane and contribute to mechanical regulation of cellular function. While the role of caveolae in membrane mechanosensation has been studied predominantly in non-cardiomyocyte cells, caveolae contribution to cardiac mechanotransduction remains elusive. Here, we studied the role of caveolae in the regulation of Ca²⁺ signaling in atrial cardiomyocytes. In Langendorff-perfused mouse hearts, atrial pressure/volume overload stretched atrial myocytes and decreased caveolae density. In isolated cells, caveolae were disrupted through hypotonic challenge that induced a temporal (<10 min) augmentation of Ca²⁺ transients and caused a rise in Ca²⁺ spark activity. Similar changes in Ca²⁺ s

SUBMITTER: Medvedev RY 

PROVIDER: S-EPMC10842990 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature