Myelination- and migration-associated genes are downregulated after phagocytosis in cultured oligodendrocyte precursor cells.

ABSTRACT: In the central nervous system, microglia are responsible for removing infectious agents, damaged/dead cells, and amyloid plaques by phagocytosis. Other cell types, such as astrocytes, are also recently recognized to show phagocytotic activity under some conditions. Oligodendrocyte precursor cells (OPCs), which belong to the same glial cell family as microglia and astrocytes, may have similar functions. However, it remains largely unknown whether OPCs exhibit phagocytic activity against foreign materials like microglia. To answer this question, we examined the phagocytosis activity of OPCs using primary rat OPC cultures. Since innate phagocytosis activity could trigger cell death pathways, we also investigated whether participating in phagocytosis activity may lead to OPC cell death. Our da

SUBMITTER: Hamanaka G 

PROVIDER: S-EPMC10842993 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature