Proteomic Indicators of Health Predict Alzheimer's Disease Biomarker Levels and Dementia Risk.

ABSTRACT:

Objective

Few studies have comprehensively examined how health and disease risk influence Alzheimer's disease (AD) biomarkers. The present study examined the association of 14 protein-based health indicators with plasma and neuroimaging biomarkers of AD and neurodegeneration.

Methods

In 706 cognitively normal adults, we examined whether 14 protein-based health indices (ie, SomaSignal® tests) were associated with concurrently measured plasma-based biomarkers of AD pathology (amyloid-β [Aβ]_42/40 , tau phosphorylated at threonine-181 [pTau-181]), neuronal injury (neurofilament light chain [NfL]), and reactive astrogliosis (glial fibrillary acidic protein [GFAP]), brain volume, and cortical Aβ and tau. In a separate cohort (n = 11,285), we examined whether protein-bas

SUBMITTER: Dark HE 

PROVIDER: S-EPMC10842994 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature