Impact of bronchopulmonary dysplasia on brain GABA concentrations in preterm infants: Prospective cohort study.

ABSTRACT:

Background

Bronchopulmonary dysplasia (BPD) is associated with cognitive-behavioral deficits in very preterm (VPT) infants, often in the absence of structural brain injury. Advanced GABA-editing techniques like Mescher-Garwood point resolved spectroscopy (MEGA-PRESS) can quantify in-vivo gamma-aminobutyric acid (GABA+, with macromolecules) and glutamate (Glx, with glutamine) concentrations to investigate for neurophysiologic perturbations in the developing brain of VPT infants.

Objective

To investigate the relationship between the severity of BPD and basal-ganglia GABA+ and Glx concentrations in VPT infants.

Methods

MRI studies were performed on a 3 T scanner in a cohort of VPT infants [born ≤32 weeks gestational age (GA)] without major structural brain injury and hea

SUBMITTER: Basu SK 

PROVIDER: S-EPMC10843009 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature