Tissue inhibitors of metalloproteinases are proteolytic targets of matrix metalloproteinase 9.

ABSTRACT: Extracellular proteolysis and turnover are core processes of tissue homeostasis. The predominant matrix-degrading enzymes are members of the Matrix Metalloproteinase (MMP) family. MMPs extensively degrade core matrix components in addition to processing a range of other factors in the extracellular, plasma membrane, and intracellular compartments. The proteolytic activity of MMPs is modulated by the Tissue Inhibitors of Metalloproteinases (TIMPs), a family of four multi-functional matrisome proteins with extensively characterized MMP inhibitory functions. Thus, a well-regulated balance between MMP activity and TIMP levels has been described as critical for healthy tissue homeostasis, and this balance can be chronically disturbed in pathological processes. The relationship between MMPs and

SUBMITTER: Coates-Park S 

PROVIDER: S-EPMC10843048 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature