Empagliflozin in Heart Failure: Regional Nephron Sodium Handling Effects.

ABSTRACT:

Significance statement

The effect of sodium-glucose cotransporter-2 inhibitors (SGLT2i) on regional tubular sodium handling is poorly understood in humans. In this study, empagliflozin substantially decreased lithium reabsorption in the proximal tubule (PT) (a marker of proximal tubular sodium reabsorption), a magnitude out of proportion to that expected with only inhibition of sodium-glucose cotransporter-2. This finding was not driven by an "osmotic diuretic" effect; however, several parameters changed in a manner consistent with inhibition of the sodium-hydrogen exchanger 3. The large changes in proximal tubular handling were acutely buffered by increased reabsorption in both the loop of Henle and the distal nephron, resulting in the observed modest acute natriuresis with these

SUBMITTER: Rao VS 

PROVIDER: S-EPMC10843196 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature