Bridging the gap between collective motility and epithelial-mesenchymal transitions through the active finite voronoi model.

ABSTRACT: We introduce an active version of the recently proposed finite Voronoi model of epithelial tissue. The resultant Active Finite Voronoi (AFV) model enables the study of both confluent and non-confluent geometries and transitions between them, in the presence of active cells. Our study identifies six distinct phases, characterized by aggregation-segregation, dynamical jamming-unjamming, and epithelial-mesenchymal transitions (EMT), thereby extending the behavior beyond that observed in previously studied vertex-based models. The AFV model with rich phase diagram provides a cohesive framework that unifies the well-observed progression to collective motility via unjamming with the intricate dynamics enabled by EMT. This approach should prove useful for challenges in developmental biolog

SUBMITTER: Huang J 

PROVIDER: S-EPMC10843280 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature