Identifying Tumor Microenvironment Biomarkers in Adherent and Cystic Vestibular Schwannomas.

ABSTRACT:

Objective

A subset of vestibular schwannomas (VSs), including cystic tumors, have higher postoperative morbidity because of the presence of adhesions between the tumor, facial nerve (FN), and brainstem. We identify tumor microenvironment (TME) biomarkers to better classify these tumors and predict the degree of tumor adherence.

Study design

Retrospective case series.

Setting

Tertiary skull base referral center.

Methods

Adult patients with cystic and solid VS matched in tumor size who underwent surgical resection were included. Expressions of seven biomarkers of extracellular matrix remodeling and tumor immune response were quantified via immunohistochemistry. The distribution of CD45+ immune cells was evaluated in intratumoral and perivascular compartments. The

SUBMITTER: Zhang L 

PROVIDER: S-EPMC10843289 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature