Critical assessment of methods of protein structure prediction (CASP)-Round XV.

ABSTRACT: Computing protein structure from amino acid sequence information has been a long-standing grand challenge. Critical assessment of structure prediction (CASP) conducts community experiments aimed at advancing solutions to this and related problems. Experiments are conducted every 2 years. The 2020 experiment (CASP14) saw major progress, with the second generation of deep learning methods delivering accuracy comparable with experiment for many single proteins. There is an expectation that these methods will have much wider application in computational structural biology. Here we summarize results from the most recent experiment, CASP15, in 2022, with an emphasis on new deep learning-driven progress. Other papers in this special issue of proteins provide more detailed analysis. For single pro

SUBMITTER: Kryshtafovych A 

PROVIDER: S-EPMC10843301 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature