A network pharmacology method explores the molecular mechanism of Coptis chinensis for the treatment of Alzheimer's disease.

ABSTRACT: To predict the molecular mechanisms of action of Coptis chinensis in the treatment of Alzheimer's disease using network pharmacology. The active ingredients and targets of Coptis chinensis were obtained from the Traditional Chinese Medicine System Pharmacology Database. Target information for Alzheimer's disease was screened using the GeneCard and OMIM databases. The Venn diagram tool was used to identify the intersecting targets of Coptis chinensis and Alzheimer's disease. The obtained target information was entered into the STRING database to construct a protein-protein interaction network. The R language was used to perform Gene ontology and Kyoto Encyclopedia of Genes and Genomes analyses of significant targets. Auto Dock Vina software was used for molecular docking. Fourteen effective

SUBMITTER: Qian Q 

PROVIDER: S-EPMC10843322 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature