A novel firmicute protein family related to the actinobacterial resuscitation-promoting factors by non-orthologous domain displacement.

ABSTRACT:

Background

In Micrococcus luteus growth and resuscitation from starvation-induced dormancy is controlled by the production of a secreted growth factor. This autocrine resuscitation-promoting factor (Rpf) is the founder member of a family of proteins found throughout and confined to the actinobacteria (high G + C Gram-positive bacteria). The aim of this work was to search for and characterise a cognate gene family in the firmicutes (low G + C Gram-positive bacteria) and obtain information about how they may control bacterial growth and resuscitation.

Results

In silico analysis of the accessory domains of the Rpf proteins permitted their classification into several subfamilies. The RpfB subfamily is related to a group of firmicute proteins of unknown function, represented by Y

SUBMITTER: Ravagnani A 

PROVIDER: S-EPMC1084345 | biostudies-literature | 2005 Mar

REPOSITORIES: biostudies-literature