Epigenetic determinants of reproductive potential augment the predictive ability of the semen analysis.

ABSTRACT:

Objective

To investigate the power of DNA methylation variability in sperm cells in assessing male fertility potential.

Design

Retrospective cohort.

Setting

Fertility care centers.

Patients

Male patients seeking infertility treatment and fertile male sperm donors.

Intervention

None.

Main outcome measures

Sperm DNA methylation data from 43 fertile sperm donors were analyzed and compared with the data from 1344 men seeking fertility assessment or treatment. Methylation at gene promoters with the least variable methylation in fertile patients was used to create 3 categories of promoter dysregulation in the infertility treatment cohort: poor, average, and excellent sperm quality.

Results

After controlling for female factors, there were signific

SUBMITTER: Miller RH 

PROVIDER: S-EPMC10843460 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature