Biomarkers and cardiovascular events in patients with stable coronary disease in the ISCHEMIA Trials.

ABSTRACT:

Importance

Biomarkers may improve prediction of cardiovascular events for patients with stable coronary artery disease (CAD), but their importance in addition to clinical tests of inducible ischemia and CAD severity is unknown.

Objectives

To evaluate the prognostic value of multiple biomarkers in stable outpatients with obstructive CAD and moderate or severe inducible ischemia.

Design and setting

The ISCHEMIA and ISCHEMIA CKD trials randomized 5,956 participants with CAD to invasive or conservative management from July 2012 to January 2018; 1,064 participated in the biorepository.

Main outcome measures

Primary outcome was cardiovascular death, myocardial infarction (MI), or hospitalization for unstable angina, heart failure, or resuscitated cardiac arrest. Seco

SUBMITTER: Newman JD 

PROVIDER: S-EPMC10843480 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature