Technical note: Impact of dose voxel kernel (DVK) values on dosimetry estimates in ¹⁷⁷ Lu and ⁹⁰ Y radiopharmaceutical therapy (RPT) applications.

ABSTRACT:

Background

Radiopharmaceutical therapy (RPT) is an increasingly adopted modality for treating cancer. There is evidence that the optimization of the treatment based on dosimetry can improve outcomes. However, standardization of the clinical dosimetry workflow still represents a major effort. Among the many sources of variability, the impact of using different Dose Voxel Kernels (DVKs) to generate absorbed dose (AD) maps by convolution with the time-integrated activity (TIA) distribution has not been systematically investigated.

Purpose

This study aims to compare DVKs and assess the differences in the ADs when convolving the same TIA map with different DVKs.

Methods

DVKs of 3 × 3 × 3 mm³ sampling-nine for ¹⁷⁷ Lu, nine for ⁹⁰ Y-were sele

SUBMITTER: Danieli R 

PROVIDER: S-EPMC10843484 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature