Multiomic analysis implicates FOXO4 in genetic regulation of chick lens fiber cell differentiation.

ABSTRACT: A classic model for identification of novel differentiation mechanisms and pathways is the eye lens that consists of a monolayer of quiescent epithelial cells that are the progenitors of a core of mature fully differentiated fiber cells. The differentiation of lens epithelial cells into fiber cells follows a coordinated program involving cell cycle exit, expression of key structural proteins and the hallmark elimination of organelles to achieve transparency. Although multiple mechanisms and pathways have been identified to play key roles in lens differentiation, the entirety of mechanisms governing lens differentiation remain to be discovered. A previous study established that specific chromatin accessibility changes were directly associated with the expression of essential lens fiber cell

SUBMITTER: Brennan L 

PROVIDER: S-EPMC10843493 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature