Regional Tau Deposition Reflects Different Pathways of Subsequent Neurodegeneration and Memory Decline in Cognitively Normal Older Adults.

ABSTRACT:

Objective

Tau pathology is recognized as a primary contributor to neurodegeneration and clinical symptoms in Alzheimer's disease (AD). This study aims to localize the early tau pathology in cognitively normal older people that is predictive of subsequent neurodegeneration and memory decline, and delineate factors underlying tau-related memory decline in individuals with and without β-amyloid (Aβ).

Methods

A total of 138 cognitively normal older individuals from the Berkeley Aging Cohort Study underwent ¹¹ C-Pittsburgh Compound-B (PiB) positron emission tomography (PET) to determine Aβ positivity and ¹⁸ F-Flortaucipir (FTP) PET to measure tau deposition, with prospective cognitive assessments and structural magnetic resonance imaging. Voxel-wise FTP anal

SUBMITTER: Chen X 

PROVIDER: S-EPMC10843500 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature