Potassium Magnesium Citrate Is Superior to Potassium Chloride in Reversing Metabolic Side Effects of Chlorthalidone.

ABSTRACT:

Background

Thiazide diuretics (TD) are the first-line treatment of hypertension because of its consistent benefit in lowering blood pressure and cardiovascular risk. TD is also known to cause an excess risk of diabetes, which may limit long-term use. Although potassium (K) depletion was thought to be the main mechanism of TD-induced hyperglycemia, TD also triggers magnesium (Mg) depletion. However, the role of Mg supplementation in modulating metabolic side effects of TD has not been investigated. Therefore, we aim to determine the effect of potassium magnesium citrate (KMgCit) on fasting plasma glucose and liver fat by magnetic resonance imaging during TD therapy.

Methods

Accordingly, we conducted a double-blinded RCT in 60 nondiabetic hypertension patients to compare the e

SUBMITTER: Vongpatanasin W 

PROVIDER: S-EPMC10843503 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature