Critical Dependence on Area in Relationship between ARMS2/HTRA1 Genotype and Faster Geographic Atrophy Enlargement: Age-Related Eye Disease Study 2 Report Number 33.

ABSTRACT:

Purpose

To analyze ARMS2/HTRA1 as a risk factor for faster geographic atrophy (GA) enlargement according to (1) GA area and (2) contiguous enlargement versus progression to multifocality.

Design

Age-Related Eye Disease Study 2 (AREDS2) cohort analysis.

Participants

Eyes with GA: 546 eyes of 406 participants.

Methods

Geographic atrophy area was measured from color fundus photographs at annual visits. Mixed-model regression of square root of GA area and proportional hazards regression of progression to multifocality were analyzed by ARMS2 genotype.

Main outcome measures

Change in square root GA area and progression to multifocality.

Results

Geographic atrophy enlargement was significantly faster with ARMS2 risk alleles (P < 0.0001) at 0.224 mm/year

SUBMITTER: Agron E 

PROVIDER: S-EPMC10843672 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature