Object-place-context learning impairment correlates with spatial learning impairment in aged Long-Evans rats.

ABSTRACT: The hippocampal formation is vulnerable to the process of normal aging. In humans, the extent of this age-related deterioration varies among individuals. Long-Evans rats replicate these individual differences as they age, and therefore they serve as a valuable model system to study aging in the absence of neurodegenerative diseases. In the Morris water maze, aged memory-unimpaired (AU) rats navigate to remembered goal locations as effectively as young rats and demonstrate minimal alterations in physiological markers of synaptic plasticity, whereas aged memory-impaired (AI) rats show impairments in both spatial navigation skills and cellular and molecular markers of plasticity. The present study investigates whether another cognitive domain is affected similarly to navigation in aged Long-E

SUBMITTER: Chen Y 

PROVIDER: S-EPMC10843702 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature