Chronic social defeat stress broadly inhibits gene expression in the peripheral taste system and alters taste responses in mice.

ABSTRACT: Human studies have linked stress exposure to unhealthy eating behavior. However, the mechanisms that drive stress-associated changes in eating behavior remain incompletely understood. The sense of taste plays important roles in food preference and intake. In this study, we use a chronic social defeat stress (CSDS) model in mice to address whether chronic stress impacts taste sensation and gene expression in taste buds and the gut. Our results showed that CSDS significantly elevated circulating levels of corticosterone and acylated ghrelin while lowering levels of leptin, suggesting a change in metabolic hormones that promotes food consumption. Stressed mice substantially increased their intake of food and water 3-5 days after the stress onset and gradually gained more body weight than that

SUBMITTER: Tu K 

PROVIDER: S-EPMC10843841 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature