Atlas of fetal metabolism during mid-to-late gestation and diabetic pregnancy.

ABSTRACT: Mounting evidence suggests metabolism instructs stem cell fate decisions. However, how fetal metabolism changes during development and how altered maternal metabolism shapes fetal metabolism remain unexplored. We present a descriptive atlas of in vivo fetal murine metabolism during mid-to-late gestation in normal and diabetic pregnancy. Using ¹³C-glucose and liquid chromatography-mass spectrometry (LC-MS), we profiled the metabolism of fetal brains, hearts, livers, and placentas harvested from pregnant dams between embryonic days (E)10.5 and 18.5. Our analysis revealed metabolic features specific to a hyperglycemic environment and signatures that may denote developmental transitions during euglycemic development. We observed sorbitol accumulation in fetal tissues and altered neu

SUBMITTER: Perez-Ramirez CA 

PROVIDER: S-EPMC10843853 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature