SQSTM1/p62 promotes the progression of gastric cancer through epithelial-mesenchymal transition.

ABSTRACT:

Background

SQSTM1/p62 is an autophagy-related receptor protein that participates in regulating tumorigenesis and multiple signaling pathways. Gastric cancer (GC) is a common tumor in the digestive tract and continues to pose a significant threat to human health. Therefore, this study aims to investigate the impact of p62 on gastric cancer.

Methods

Immunohistochemistry and Western blotting were employed to assess the expression level of the p62 protein in gastric cancer tissues and its correlation with prognosis. Subsequently, in vitro cell experiments were conducted to determine the role of p62 in gastric cancer cell proliferation, migration, and metastasis.

Result

The expression of p62 in gastric cancer tissues was significantly higher than in normal tissues. The exp

SUBMITTER: Xu Y 

PROVIDER: S-EPMC10844054 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature