Prognostic impact of CEBPA mutational subgroups in adult AML.

ABSTRACT: Despite recent refinements in the diagnostic and prognostic assessment of CEBPA mutations in AML, several questions remain open, i.e. implications of different types of basic region leucin zipper (bZIP) mutations, the role of co-mutations and the allelic state. Using pooled primary data analysis on 1010 CEBPA-mutant adult AML patients, a comparison was performed taking into account the type of mutation (bZIP: either typical in-frame insertion/deletion (InDel) mutations (bZIP^InDel), frameshift InDel or nonsense mutations inducing translational stop (bZIP^STOP) or single base-pair missense alterations (bZIP^ms), and transcription activation domain (TAD) mutations) and the allelic state (single (smCEBPA) vs. double mutant (dmCEBPA)). Only bZIP^InDel pa

SUBMITTER: Georgi JA 

PROVIDER: S-EPMC10844079 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature