Effect of Shenlingyigan decoction on inflammatory factors related to liver injury regulated by TLR3 signaling pathway.

ABSTRACT:

Background

To investigate the therapeutic effect of Shenlingyigan decoction on acute liver injury. Further explored the mechanisms involved in the therapeutic properties of Shenlingyigan decoction by test several key proteins (TLR3, TRIF, TBK1, IRF3, IFNβ, IL-1 and IL-6) within the TLR3 signaling pathway.

Methods

The mouse acute liver injury model group was established by pretreatment with D-GalN and Poly (I:C) induction. The acute liver injury mouse treatment groups were gavage with different doses of Shenlingyigan decoction for 3 days. The therapeutic effects of Shenlingyigan decoction were preliminarily evaluated using organ indices, tissue images, and HE staining. Furthermore, potential associated signaling pathways and target effects were pre

SUBMITTER: Liu X 

PROVIDER: S-EPMC10844112 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature