Expression of erythropoietin receptor protein in the mouse hippocampus in response to normobaric hypoxia.

ABSTRACT:

Background

Over the past decades, accumulating research on erythropoietin (EPO) and its receptor (EPOR) has revealed various neuroprotective actions and upregulation in hypoxic conditions. To our knowledge, EPOR protein levels in the hippocampus and isocortex have never been measured. Therefore, the aim of this study was to measure EPOR protein in the hippocampus (HPC) and prefrontal cortex (PFC). Further objectives were to examine the effects of exposure to normobaric hypoxia of various degrees and durations on EPOR protein and to explore how long-lasting these effects were.

Method

Adult C57BL/6 mice were randomized into a control group (N = 12) or various hypoxia groups (N = 5-11). Mice were exposed to three different O₂ concentrations (10 %, 12 %, or 18 %) for

SUBMITTER: Fussing F 

PROVIDER: S-EPMC10844123 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature