Fronto-striatal alterations correlate with apathy severity in behavioral variant frontotemporal dementia.

ABSTRACT: Structural and functional changes in cortical and subcortical regions have been reported in behavioral variant frontotemporal dementia (bvFTD), however, a multimodal approach may provide deeper insights into the neural correlates of neuropsychiatric symptoms. In this multicenter study, we measured cortical thickness (CTh) and subcortical volumes to identify structural abnormalities in 37 bvFTD patients, and 37 age- and sex-matched healthy controls. For seed regions with significant structural changes, whole-brain functional connectivity (FC) was examined in a sub-cohort of N = 22 bvFTD and N = 22 matched control subjects to detect complementary alterations in brain network organization. To explore the functional significance of the observed structural and functional deviations, correlation

SUBMITTER: Upadhyay N 

PROVIDER: S-EPMC10844138 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature