Multi-modal MRI of hippocampal morphometry and connectivity after pediatric severe TBI.

ABSTRACT: This investigation explores memory performance using the California Verbal Learning Test in relation to morphometric and connectivity measures of the memory network in severe traumatic brain injury. Twenty-two adolescents with severe traumatic brain injury were recruited for multimodal MRI scanning 1-2 years post-injury at 13 participating sites. Analyses included hippocampal volume derived from anatomical T1-weighted imaging, fornix white matter microstructure from diffusion tensor imaging, and hippocampal resting-state functional magnetic resonance imaging connectivity as well as diffusion-based structural connectivity. A typically developing control cohort of forty-nine age-matched children also underwent scanning and neurocognitive assessment. Results showed hippocampus volume was decr

SUBMITTER: Guerrero-Gonzalez JM 

PROVIDER: S-EPMC10844146 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature