VEGF-A-induced changes in distal outflow tract structure and function.

ABSTRACT:

Purpose

To investigate changes in distal outflow tract vessels caused by VEGF-A and their impact on outflow.

Methods

We compared VEGF-A perfused porcine anterior segments with and without trabecular meshwork (TM) to control eyes. In the first experiment (n=48), we analyzed live changes of the outflow tract with spectral-domain optical coherence tomography (SD-OCT) over 3 h and reconstructed them in 3D. In a second experiment (n=32), we measured the intraocular pressure (IOP) variation in response to VEGF-A over 48 h and computed the outflow facility.

Results

VEGF-A increased the vessel volume of the distal outflow tract by 16.8±10.6% while control eyes remained unchanged (0.5±6.8%). Volume changes occurred within the first 100 min before plateauing at 140 min. VEGF-A

SUBMITTER: Oltmann J 

PROVIDER: S-EPMC10844149 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature