Top IHC/ISH Hacks for and Molecular Surrogates of Poorly Differentiated Sinonasal Small Round Cell Tumors.

ABSTRACT:

Background

Poorly differentiated sinonasal small round cell tumors (SRCTs) are rare and heterogeneous, posing challenges in diagnosis and treatment.

Methods

Recent advances in molecular findings and diagnostic refinement have promoted better understanding and management of these tumors.

Results

The newly defined and emerging sinonasal entities demonstrate diverse morphologies, specific genomic signatures, and clinical behavior from conventional counterparts. In this review of SRCTs, emphasis is placed on the diagnostic approach with the employment of a pertinent panel of immunohistochemistry studies and/or molecular tests, fine-tuned to the latest WHO 5 classification of sinonasal/paranasal tumors and personalized treatment.

Conclusion

Specifically, this review

SUBMITTER: Bell D 

PROVIDER: S-EPMC10844182 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature