Impact of modeled microgravity stress on innate immunity in a beneficial animal-microbe symbiosis.

ABSTRACT: The innate immune response is the first line of defense for all animals to not only detect invading microbes and toxins but also sense and interface with the environment. One such environment that can significantly affect innate immunity is spaceflight. In this study, we explored the impact of microgravity stress on key elements of the NFκB innate immune pathway. The symbiosis between the bobtail squid Euprymna scolopes and its beneficial symbiont Vibrio fischeri was used as a model system under a simulated microgravity environment. The expression of genes associated with the NFκB pathway was monitored over time as the symbiosis progressed. Results revealed that although the onset of the symbiosis was the major driver in the differential expression of NFκB signaling, the stress of simulate

SUBMITTER: Duscher AA 

PROVIDER: S-EPMC10844198 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature