Realtime monitoring of thrombus formation in vivo using a self-reporting vascular access graft.

ABSTRACT:

Background

Chronic kidney disease (CKD) affects 10% of the global population costing over a hundred billion dollars per annum and leading to increased risk of cardiovascular disease. Many patients with CKD require regular haemodialyses. Synthetic arteriovenous grafts (AVG) are increasingly used to provide rapid vascular connection for dialysis. Initially, they have excellent patency rates but are critically limited by neointimal hyperplasia at the venous anastomosis, which drives subsequent thrombosis, graft failure and death.

Methods

Here, we describe a system in which electrical impedance spectroscopy sensors are incorporated circumferentially into the wall of a synthetic arteriovenous graft. This is combined with an implantable radiotelemetry system for data transmission

SUBMITTER: Hoare D 

PROVIDER: S-EPMC10844314 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature