Association between weight cycling and risk of colorectal cancer: a prospective cohort study.

ABSTRACT:

Background

Weight cycling is the repeated episodes manifesting intentional weight loss and subsequent unintentional weight gain. Whether the frequency and magnitude of weight cycling is associated with colorectal cancer risk independent of body mass index (BMI) remains unknown.

Methods

Two prospective cohort studies, Nurses' Health Study I and Health Professionals Follow-up Study, followed 85,562 participants from 1992 to 2014. Participants completed a questionnaire regarding the frequency and magnitude of intentional weight loss in the past 4 years at the baseline. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazard model.

Results

We identified 1626 colorectal cancer cases during up to 22 years of follow-up. In the pool

SUBMITTER: Kim S 

PROVIDER: S-EPMC10844329 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature