Dose-response effects on HbA_1c and bodyweight reduction of survodutide, a dual glucagon/GLP-1 receptor agonist, compared with placebo and open-label semaglutide in people with type 2 diabetes: a randomised clinical trial.

ABSTRACT:

Aims/hypothesis

The aim of this study was to assess the dose-response effects of the subcutaneous glucagon receptor/glucagon-like peptide-1 receptor dual agonist survodutide (BI 456906) on HbA_1c levels and bodyweight reduction.

Methods

This Phase II, multicentre, randomised, double-blind, parallel-group, placebo-controlled study, conducted in clinical research centres, assessed survodutide in participants aged 18-75 years with type 2 diabetes, an HbA_1c level of 53-86 mmol/mol (7.0-10.0%) and a BMI of 25-50 kg/m² on a background of metformin therapy. Participants were randomised via interactive response technology to receive survodutide (up to 0.3, 0.9, 1.8 or 2.7 mg once weekly [qw; dose group (DG) 1-4, respectively] or 1.2 or 1.8 mg twice we

SUBMITTER: Bluher M 

PROVIDER: S-EPMC10844353 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature