Critical ICP thresholds in relation to outcome: Is 22 mmHg really the answer?

ABSTRACT:

Purpose

Intensive care for patients with traumatic brain injury (TBI) aims, among other tasks, at avoiding high intracranial pressure (ICP), which is perceived to worsen motor and cognitive deficits and increase mortality. International recommendations for threshold values for ICP were increased from 20 to 22 mmHg in 2016 following the findings in a study by Sorrentino et al., which were based on an observational study of patients with TBI of averaged ICP values. We aimed to reproduce their approach and validate the findings in a separate cohort.

Methods

Three hundred thirty-one patients with TBI were included and categorised according to survival/death and favourable/unfavourable outcome at 6 months (based on Glasgow Outcome Score-Extended of 6-8 and 1-5, respectively). Rep

SUBMITTER: Riparbelli AC 

PROVIDER: S-EPMC10844356 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature